Acute and Subchronic Toxicities of the Aqueous Extract of the Hymenocardia acida (Euphorbiaceae) Roots in Rodents

The roots of Hymenocardia acida are used in traditional African medicine to treat mainly erectile dysfunction. This study aims evaluate the lethal and sub-lethal toxicities aqueous extract two rodents species, namely Mus musculus Rattus norvegicus. acute intraperitoneal oral were determined by method Miller Tainter. Subchronic toxicity with doses 500 1000 mg/kg body weight was assessed according slightly modified OECD 408 method. results showed that 50% dose 223.87 mice. In addition, mice greater than 12,000 weight. subchronic study, induced a significant (P < .001) increase white blood cell count at after 60 days treatment. From thirtieth day treatment onwards, .05) reduction glucose levels dose. Aqueous is toxic route exerts non-specific immunity action high doses. It harmless rats mg/Kg